fecal transplants in canine patients with acute diarrhea
|fecal transplants in canine patients with acute diarrhea|
medical news is full of studies on the microbiota, and everything especially that of the gastrointestinal system. despite the fact that
as a result, we still know too little about its very complex role in health and disease. the digestive microbiota would contribute to maintaining the health of its host via immunomodulation, providing a nutritional substrate and providing the first line of defense against intestinal pathogens. the microbiota refers to the body microbial population quantitatively and qualitative.
Historically, traditional medicine has focused on pathogens and their roles in disease. Good that this approach allows a certain understanding of the pathophysiology of diseases, it fails to take into account consideration of the significant influence of the pathogen on the microbiota and the consequences of this interaction on the illness. Alterations in the digestive flora, known as the name of dysbiosis are currently at the center of research gastroenterology scientists. This new interest stems from advances in microbial genetic identification (PCR), which allows a more objective assessment of the nature of microbial changes during diseases and the effects of the different modulator treatments.
In veterinary medicine, studies on the molecular evaluation of intestinal microbiome have identified the presence of bacterial and fungal dysbiosis in the duodenum of dogs with inflammatory disease of the intestine (IBD). this dysbiosis can result in a turnaround of the microbiota, characterized by, among other things, a decrease in the clostridial genus and an increase in proteobacteria. the presence of proteobacteria seems to be an important indicator of dysbiosis. Several other qualitative alterations of the intestinal flora have been demonstrated in dogs with acute and chronic intestinal diseases.
compared to healthy dogs, the following are noted in canine patients with acute diarrhea, especially those of a hemorrhagic nature, a significant increase in the Suterella genus and clostridium per fingers. dogs in the clinically active phase of IBD have a decrease in species Faecalibacterium and Fusobacteria, and this decrease appears to be recovering during clinical remission.
these bacterial species are decreasing during diarrhea are important producers of short chain, with beneficial health effects are well known. all this data we suggest that the various strategies to handling the intestinal microbiota are of first importance in the management of digestive diseases. Several treatments already commonly used in veterinary gastroenterology have the potential to have an effect on the digestive microbiota: diet, antibiotics, and probiotics. although in some very effective cases, antibiotics (metronidazole and tylosin) have the disadvantage of not being targeted and sometimes ineffective in the medium and long term.
The infusion of suspended fecal material from
from one healthy living being to another is
a practice as old as the earth... or almost!
In the 4th century, the Chinese alchemist Ge Hong described its oral administration to patients with
severe diarrhea. We still find this technique
nowadays in China, under the name of the soup
yellow or golden. In the middle of the 20th century, we observe a growing interest within the community scientific for fecal transplants. Afterward that an astonishing number of clinical remissions of secondary recurrent pseudomembranous colitis to clostridium difficult has been achieved through fecal transplants when a prognosis rather reserved for them was previously reserved for them, medicine is now
is more interested. this field of interest has even been extended to chronic digestive diseases such as than crohn's disease and ulcerative colitis.
Fecal transplants in pets have since then a few years have been practiced extensively for a variety of canine digestive conditions and on a smaller feline scale. However, the available information remains anecdotal and no studies have been carried out.
has so far evaluated its use and effectiveness in a manner that is consistent with the objective. several protocols are described, but there is currently no scientific consensus on donor selection, sample collection, and storage, or on the ideal method of administration. currently, research projects on the subject are and a growing number of internal medicine specialists veterinary surgeon is interested in and practices them.
based on human experience and information currently available in veterinary medicine, fecal transplants appear to be a safe, promising treatment option, to be considered in gastroenterology. other researchers even hypothesize that non-specific handling of the microbiota may also have a role in the treatment of extra digestive diseases such as diabetes, obesity and potentially many others...